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Combined together, our results indicate that the inhibition of STAT3, G6PD and TrxR1 functions by R001 leads to ROS production and oxidative stress, which induce an antitumor cell response in the TNBC models
The GS-ylation of proteins serves as a protective mechanism against irreversible oxidative or nitrosative damage as well as a means of GSH storage [16,22]
Kurtz, J
International Journal of Biochemistry & Cell Biology, 34 (11), 13951400
doi: 10.1016/j.jcmgh.2019.04.015 97 WangAWWangensteenKJWangYJZahmAMMossNGErezNet al
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