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Structurally, semaglutide is a modified peptide analog of human GLP-1, designed to resist enzymatic degradation and prolong its biological half-life, allowing for once-weekly subcutaneous injection

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63 Furthermore, BCAT 1 is selectively upregulated in isocitrate dehydrogenase (IDH) wild-type (WT) GBM, and -ketoglutarate (-KG) mediates cell death in BCAT 1-deficient IDH WT GBM