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Do maternal folate and homocysteine levels play a role in neurodevelopmental processes that increase risk for schizophrenia

10.1111/tpj.14517 [DOI] [PubMed] [Google Scholar] 19.Li F, Dong C, Yang T, Ma J, Zhang S, Wei C, et al

Zhang randomized controlled study

Subjective evaluations Skin whitening and smoothening at the test site and improvement in fine lines were evaluated subjectively by the investigator and by the subjects in accordance with the following scoring pattern: 3= marked deterioration 2= moderate, visibly uneven deterioration 1= slight deterioration 0= no perceptible change or improvement 1= slight change or improvement 2= moderate change or improvement (whitening

This stage typically enrolls 100 to 300 patients who actually have the disease of interest to determine if the drug works, identify optimal dosing regimens, and monitor for short-term adverse effects

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