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Oligospermia may occur after prolonged administration or excessive dosage

Effects of pentoxifylline on inflammatory parameters in chronic kidney disease patients: a randomized trial

Increased mRNA expression of osteoprotegerin (OPG), while decreased receptor activator of nuclear factor kappa B ligand (RANKL) mRNA expression, resulting in an increased OPG/RANKL ratio.\nSignificantly increased mRNA expression of BMP2, runt-related transcription factor 2 (Runx2), and osterix (Osx) in a dose-dependent manner

This imbalance significantly disrupts the basal ganglia circuitry, leading to the hallmark motor symptoms of PD, including tremors, bradykinesia, and rigidity

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Further results with isatuximab and daratumumab in NDMM with combination regimens such as bortezomib-lenalidomide-dexamethasone or carfilzomib-lenalidomide-dexamethasone are awaited with interest (NCT03319667, NCT03617731, NCT04483739, NCT03710603, NCT03652064)
