analysis of the glutathione s-transferase gst gene family transferases: substrates, inihibitors and pro-drugs in cancer and neurodegenerative diseases Glutathione Transferases Are Involved in
Description
Transgenic mice in which GCLC expression is abolished in hepatocytes have 58% of normal hepatic GSH levels and manifest liver pathologies characteristic of the various clinical stages of fatty liver disease 8,9

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Journal of Biological Chemistry, 284 (20), 1384313855
The authors concluded that glutathione, with or without vitamin C and NAC, was well tolerated but did not produce measurable therapeutic benefit in this cohort (Williams et al., 2025)
