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In addition to its effects on neurotransmitters, the sleep peptide influences hormonal activity by lowering ACTH levels, which reduces stress-related cortisol production, and by enhancing growth hormone (GH) secretion, essential for restorative sleep

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On the one hand, other SCFAs produced by Clostridium exert immunomodulatory effects in T1D by reducing intestinal permeability (192)

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FIGURE 3 We conducted a direct comparison of the whole proteome of the GF-HLC and SM-HLC datasets

Circ Res 90:966973 Carmeliet P, Ferreira V, Breier G, Pollefeyt S, Kieckens L, Gertsenstein M, Fahrig M, Vandenhoeck A, Harpal K, Eberhardt C et al (1996) Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele