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There is robust evidence that such mechanisms involve or even trigger the dysregulation of the immune system and the excessive activation of specific inflammatory pathways

Lv J, Zhao D, Zhao G, Xie Z (2022) Efficacy and safety of butylphthalide in secondary prevention of stroke: study protocol for a multicenter, real world trial based on Internet

For instance, hypoxia induces extracellular signal-regulated kinase 1/2 (ERK1/2) phosphorylation to activate HIF-1, which directly binds to the promoter of ABCG2 gene and subsequently enhances ABCG2 transcription, leading to gemcitabine chemoresistance in pancreatic cancer cells (He et al., 2016)

.Li, H., Toh, P

9 Solubility Drug solubility in the nasal physiological fluid can influence the extent of nasal absorption

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