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In a systematic review and meta-analysis of four randomized controlled trials including over 3,700 subjects, combination therapy with an SGLT2 inhibitor and metformin beginning at diabetes diagnosis resulted in greater weight loss and reduction of HbA1C levels compared with either drug alone
What a given dose feels like depends on which of the three arms it leans on, and on the body it lands in
If you are comfortable with smaller volume measurements, 0.5mL of water creates a more concentrated solution that preserves syringe volume for larger future doses
Adjustments must be data-driven
Another study by Pickart et al
