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Withania somnifera modulates cancer cachexia associated inflammatory cytokines and cell death in leukaemic THP-1 cells and peripheral blood mononuclear cells (PBMCs)

HIF- is hydroxylated by prolyl hydroxylases (PHDs) that are recognized by the von HippelLindau protein (pVHL), causing HIF- to be ubiquitinated and degraded by the proteasome