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Does not significantly inhibit related SAM-dependent methyltransferases or enzymes in the NAD+ salvage pathway NAD+ increase : By preventing nicotinamide methylation to 1-MNA, more nicotinamide remains available for conversion to NMN and subsequently to NAD+ via the salvage pathway

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When NNMT is inhibited by compounds like 5-Amino-1MQ, more nicotinamide becomes available for conversion to NAD+ via NAMPT

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