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Sleep-disordered breathing and the current epidemic of obesity: consequence or contributing factor

Internalization of OR has been demonstrated in different models with different technical approaches but some discrepancies have been reported

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[DOI] [PMC free article] [PubMed] [Google Scholar] 197.Lopez-Tobon A., Shyti R., Villa C.E., Cheroni C., Fuentes-Bravo P., Trattaro S., Caporale N., Troglio F., Tenderini E., Mihailovich M., et al

Recommended dosing of 1-2 mg subcutaneous injection 2-3x per week (6 mg/week total) compares to toxic dose estimated at ~22,500 mg (approximately 3,750 times higher than weekly dose)

Moreover, pad2-1 exhibited significantly higher biomass than WT at 700 M (Fig