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First, the effect is enzymatic and cumulative you are shifting a metabolic set-point over days and weeks, not triggering an acute hormonal event, which is why steady daily exposure matters more than any single large dose

While no major safety flags have emerged from either the scientific literature or widespread anecdotal use, the absence of large-scale human data means users should proceed carefullyespecially if considering high doses or long-term use

doi: 10.1016/j.jchf.2017.08.015

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