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T cell exhaustion is well documented in viral infections and various cancer settings and is hypothesized to arise at least in part due to chronic antigen stimulation, though the pathways leading to exhaustion, particularly in the cancer setting, remain incompletely defined (208)
Results can vary between first-time and repeat patients , with repeat patients often experiencing longer-lasting relief as muscle and nerve activity gradually decrease over time
In that year and 2023, the FDA and European Medicines Agency (EMA) approved sodium thiosulfate (PEDMARK and Pedmarqsi, respectively) therapy for reducing cisplatin ototoxicity in children suffering from non-metastatic solid tumours [77,78,79,80]
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[DOI] [PMC free article] [PubMed] [Google Scholar] 26.Pardridge WM
Understanding these mechanisms may provide new targets for interventions aimed at mitigating age-associated diseases
