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In 2018, a Biochemical Pharmacology study reported that membrane-permeable NNMT inhibitors given to obese mice cut white fat mass and body weight and shrank adipocytes [5]

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In parallel, studies have reported modulation of early growth response-1 (EGR-1) expression and its regulatory partner NAB2, which are involved in cytokine signaling and early extracellular matrix formation during cellular response processes [2]