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Description
Perhaps the most devastating impact of B12 pathway dysfunction in chronic illness occurs within the central nervous system
Methods for the analysis of vitamin B 12 in food Several methods have been used to determine the vitamin B 12 content in foods including microbiological assays, chemiluminescence assays, polarographic, spectrophotometric, and high-performance liquid chromatography processes
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Clinical evidence for this mechanism in humans is limited
In vitamin B 12 deficiency, the mutase reaction is impaired, causing accumulation of D-methylmalonyl-CoA, which is converted to methylmalonic acid
