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10.13263/j.cnki.nja.2018.07.010 75 YangF.WeiY.LiaoB.WeiG.QinH.PangX.et al (2018b)

Additionally, ferulic acid exhibits antioxidant activity by upregulating nuclear factor erythroid 2related factor 2 (Nrf2) signaling and inducing superoxide dismutase (SOD), glutathione peroxidase (GPx) antioxidant enzymes in the injured brain (Sun, Ma, Li et al., 2022)

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They found that SLC7A11 downregulation in ALI exacerbates carbon tetrachloride-induced ferroptosis, while MSC-Exos enhance SLC7A11 expression via CD44 and OTUB1 upregulation, supporting antioxidant defenses

the two components most vulnerable to oxidative damage due to increased mass of polyunsaturated fatty acids and respiratory activity in neurons
