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The biological half-lifes of TAM and its metabolites in blood or brain were determined after reaching maximum by non-linear regression (one-phase decay, GraphPad Prism 7, GraphPad Software Inc., La Jolla CA, USA)

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The circulating human erythrocytes are able to scavenge O 2 and H 2 O 2 by SOD, CAT, and GPx-dependent mechanisms may be important in regulating such reactions