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JAMA Intern Med 2016;176(9):13711378

Asian J Pharm Res Health Care

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It has been found that smooth muscle cells in COPD patients exhibit mitochondrial dysfunction, which in turn causes an increase in mitochondrial ROS, resulting in an oxidative-oxidative imbalance that contributes to the development and progression of COPD

Among these GPxs, 5 selenium-dependent GPx isozymes have been identified (Table 1)