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Thyroid function, represented by thyroid stimulating hormone (TSH) and free thyroxine (T4), is also known to be partly genetically determined

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Lipopolysaccharides and Toll-like receptor (TLRs) mediated differentiation of M1 macrophages are associated with a metabolic shift towards glycolysis, blocking it by glucose derivate like 2-deoxyglucose impairs both ROS and pro-inflammatory cytokine production

Given the oxidative stress caused by -CG administration 7 , we proposed that ROS play a critical role in elevating autophagy activity in enterocytes
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