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It regulates TAMs by promoting their polarization into the M2 phenotype, which is tumor-supportive

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HIIT increases MOTS-C production by up to 11.9 times in muscle tissue, activates AMPK pathways, and creates an "afterburn" effect that elevates metabolism for hours after the session

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Tumors evade immune cytotoxicity by altering the surface topology of NK cells

This entire process, which is a critical means of energy production, produces ROS as a major byproduct [27]