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While PCAC recommendations are advisory, these proceedings function as a clear public statement of the FDAs thinking
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Recently it was suggested that serial plasma measurements (i.e

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Pavese C, Cecini M, Camerino N et al (2014) Functional and social limitations after facial palsy: expanded and independent validation of the Italian version of the facial disability index

Trials have typically used titration periods of about 6 weeks, starting at a lower dose and stepping up to the full maintenance dose
