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141 In the European Union, member states grant conditional marketing authorization (CMA) to COVID-19 medicines through EMA

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doi: 10.1023/B:NEON.0000013484.73208.a4

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SIRT Sirtuins, are a family of nicotinamide adenine dinucleotide (NAD)-dependent histone deacetylases, which respond to ROS-activated NAD + function to regulate numerous antioxidant and redox signalling pathways through transcription factors (including Nrf2, p53, NF-B, FOXO, PGC-1a) and several molecules of antioxidant response element (ARE) 135