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inadequate control for demographic confounders, potentially introducing confounding bias

Median age was 44 years (range, 2558 years), 11 (69%) were male, and median number of prior biologic exposures was 3 (range, 25)

10.1177/1177271917691035 [DOI] [PMC free article] [PubMed] [Google Scholar] 105.Khemakhem AM, Frye RE, El-Ansary A, Al-Ayadhi L, Bacha AB

Wasp regulates suppressor activity of human and murine cd4(+)Cd25(+)Foxp3(+) natural regulatory T cells

These findings indicate a possible inhibition of inflammation

These exposures may cause localized inflammation and the release of reactive oxygen species (ROS) within colorectal tissues, which may be causative or promotive of neoplastic processes