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(A) The structure of hepatocyte growth factor (HGF) includes a -chain (69 kDa) of four Kringle domains and a -chain (43 kDa) consisting of a serine proteinase homology (SPH) domain linked by disulfide bonds

Start low, assess response over two weeks, and adjust based on subjective and objective cognitive metrics

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data strongly suggest that almost any binding is pH-dependent and to be correctly modeled, the protonation states must be properly assigned prior to and after the binding
