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We showed that HSV-1 enhanced the Keap1-dependent ubiquitination and degradation of Nrf2, which resulted in substantial reductions in the expression levels of antioxidative genes, thereby disturbing cellular redox homeostasis and promoting ferroptosis

Nuclear factor-kappa B (NF-B) plays a crucial role in numerous inflammatory and immune processes

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2017;114:E4095E4102

ONC201 induces p53-independent apoptosis and cell cycle arrest in hematological malignancies and leukemic stem/progenitor cells by inducing ER stress and mTOR inhibition

Mutations and GST pulldown were used to validate the model, which serves as a good example of rational design