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As we get older, this absorption problem compounds: the body's ability to absorb nutrients through digestion decreases progressively, and some adults become completely unable to absorb B12 orally regardless of dose

Mol Cell Biol

(1) Cox HD, Smeal SJ, Hughes CM, Cox JE, Eichner D

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Meta-analysis of these datasets indicates that the excess CHD risk in TT homozygotes compared to CC homozygotes was 2% (much lower than predicted from the prospective observational studies), a nonsignificant difference (that is, it could have occurred by chance)