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That process can be additionally promoted by cellular aging, which is associated with accumulating mutations in epigenetic machinery and dysregulation of cellular metabolism [216], or by certain therapeutic interventions [217]

Best practices for single-cell analysis across modalities

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However, therapeutically exploiting NK2R signalling has previously been unattainable because its endogenous ligand, neurokinin A, is short-lived and lacks receptor specificity 5,6
