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For instance in vitro studies and experiments performed in cells expressing insulin receptor showed that PKCs phosphorylate specific serine/threonine residues of insulin receptor and its intracellular substrates belonging to the family of insulin receptor substrates (IRSs), causing impairment of insulin signaling pathway [30,31,32,33,34,35]

C-Reactive Protein Test: Uses and Indications, Benefits, Types, Preparation, Procedure and more What is C-reactive protein (CRP)

RNA extraction was performed via a standard chloroform/phenol and isopropanol precipitation method

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[8] Signaling Pathway [edit] Phosphoinositide-specific phospholipase C (PLC) is a key player in cell signaling processes