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Excess B12 from oral supplements is poorly absorbed at high doses (the body absorbs roughly 1 to 2% of a 1,000 mcg oral dose) and the remainder is excreted in urine

doi: 10.1016/j.tips.2012.09.007

Care 22 GuguinouM.ChantmeA.FromontG.BougnouxP.VandierC.Potier-CartereauM

Pape, L., Ahlenstiel-Grunow, T., Birtel, J., Krohne, T

The matter with glutathione is straightforward to explain

Thus, while nutraceuticals hold promise for cancer chemoprevention, their safe and effective use requires further largescale, longterm clinical trials to define optimal forms, dosages, and populations