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622 The future challenge lies in discovering new, safe immunomodulatory drugs that act specifically on epigenetics, as epigenetic modifications are highly subject to variations influenced by micronutrients, diet, and/or physical activity

7.7 Tumor necrosis factor signaling pathway Tumor necrosis factor-alpha (TNF-) is a 26-kDa transmembrane precursor protein (mTNF) that is cleaved by TNF-alpha-converting enzyme (TACE, ADAM17) to generate soluble protein (sTNF) (Schwarz et al., 2013)

The mushroom's color changes from pure white to cream as it matures and eventually yellows or browns with age [1]

These natural compounds modulated tp53 mRNA expression, demonstrating their efficacy in key neuroprotective pathways (Li YQ et al., 2020)

Molecular mechanisms controlling cortical gliogenesis

(3) Current ferroptosis inhibitors (e.g., Ferrostatin-1) exhibit limitations such as low blood-brain barrier penetration and poor tissue specificity, while clinically used iron chelators (e.g., deferoxamine) may interfere with physiological iron homeostasis