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References: Sikiric, P., Blagaic, A

299 , F436F444 (2010)

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TGF- secreted by tumor vascular endothelial cells can induce differentiation of endothelial cells and adjacent fibroblasts into myofibroblasts through both autocrine and paracrine mechanisms (193)

Interestingly, despite the activation of caspases in late stages of parthanatos, caspase inhibitors cannot inhibit the parthanatos process except for blocking PARP1 activity, confirming that PARP1-mediated cell death is caspase-independent [137, 139]

XOI allopurinol and URAT1 inhibitor benzbromarone) effectively reduce SUA levels, their clinical utility is constrained by significant organ toxicity risks (Wu F