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As noted by Kraus et al., Nature Medicine , NNMT inhibition in white adipose tissue significantly increased energy expenditure and reduced fat mass in animal models without changes to diet or activity

As well as from poor diet and digestion, vitamin B12 deficiencies can also be affected by a genetic condition such as: o Pernicious anaemia o Crohns disease o Treatment with proton-pump inhibitors o Atrophic gastritis o Coeliac disease o Use of antacids (acid is required to release B12 from food) o Gastrointestinal surgery o Use of certain medications o Use of illegal drugs and substances including nitrous oxide

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These improvements occurred even in subjects who lost only modest amounts of weight, suggesting metabolic benefits beyond simple weight reduction

All available data are from animal trials or studies on AOD-9604