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In DIO rats, RM-718 demonstrated comparable activity to setmelanotide on weight and food intake reduction in a 14-day study ( Currently, RM-718 is being tested in a four-part phase I clinical trial in participants with general obesity, HO, and Prader-Willi Syndrome (NCT06239116)

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Their study also demonstrated its potential antioxidant protection against ROS damage [209]

[24] [25] The endogenous agonists of melanocortin 4 receptor include -MSH, -MSH, -MSH, and ACTH

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