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The complex travels through the small intestine until it reaches the terminal ileum, where specialised receptors called cubam (a complex of cubilin and amnionless proteins) recognise and facilitate the uptake of the B12-IF complex into enterocytes (intestinal cells)

AIF is translocated to the nucleus, where the protein causes chromatin condensation and DNA fragmentation, thus initiating caspase-independent apoptosis

[DOI] [PMC free article] [PubMed] [Google Scholar] 101.Davis C., Carberry S., Schrettl M., Singh I., Stephens J.C., Barry S., Kavanagh K., Challis G., Brougham D., Doyle S

They also undergo strict lab testing to ensure they meet our rigorous quality standards for purity and potency