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The inflammatory cellular infiltration, such as neutrophils and macrophages, mediating prolonged airway inflammation can be induced, and inflammatory cytokines are released, such as TNF- as an initial proinflammatory cytokine stimulating the expression of downstream cytokines, such as IL-1(6)

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Texture descriptors including entropy, energy, contrast, correlation, and homogeneity were computed across four angular directions (0, 45, 90, 135) with a pixel offset of 1, and the mean value for each nucleus was measured

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