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Additionally, esculetin (20-80 mg/kg) inhibits tBCCAO-induced activation of the mitochondrial apoptosis pathway and autophagy in mice by reducing the expression levels of autophagy-related factors (such as Bnip3, Beclin1, Pink1 and parkin) and apoptosis-related factors (such as p53, Bax and caspase 3) by activating the Nrf2 signaling pathway (43)
Science 377 , eabo7257 (2022)

Morando F, Rosi S, Gola E et al (2014) Adherence to a moderate sodium restriction diet in outpatients with cirrhosis and ascites: a real-life cross-sectional study

10.1038/ng.485 184 SauerH.OertelW

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