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BV biofilms are often resistant to antibiotics and can recur due to the existence of persister cells that have decreased metabolic activity and the physical barrier the biofilms create blocking antibiotics from accessing microbes within the extracellular polymeric substances, among other mechanisms 15,22,23

Th17 cells, an immune player, induce neuroinflammation, causing demyelination and obstructing nerve signal transmission

It is not clear how important these side reactions are to the metabolism of most cysteine S -conjugates in the intact animal, but there is no doubt that they do occur in vivo with some cysteine S -conjugates

J Appl Biomed

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[8] Patients with significant alcohol intake or thiamine deficiency also require precaution: chronic heavy alcohol use can deplete thiamine (vitamin B) and taking ALA in the setting of thiamine deficiency has been associated with serious health risks (including a condition resembling Wernickes encephalopathy)