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This is supported by the fact that reactivation of latent pathogens increases during periods of increased immunodeficiency, which results in disease outbreaks throughout the year depending on whether they are reactivated or not, as occurs in systemic lupus erythematosus [240]

Standard urine drug tests are designed to identify specific small-molecule substances of abuse such as amphetamines, benzodiazepines, cannabinoids, cocaine, opioids, and phencyclidine

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However, the iSPN + mut population at 3 months had already impacted numerous marker genes (Extended Data Fig