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Alternatively, GSK-3 phosphorylates and activates STAT3 by promoting its association with the pro-inflammatory interferon- (IFN-) receptor in mouse primary astrocytes, by mechanisms which appear independent of TLR4

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Mycobacterium tuberculosis & silica sand are swallowed by phagocytes, which rupture lysosomes to release hydrolase and promotes inflammation, eventually leading to the death of phagocytes

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