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(5) Studies have shown that IGF-DES activates the IGF-1R with similar affinity to native IGF-1, triggering receptor autophosphorylation and activation of the PI3K/AKT and MAPK/ERK pathways

The conserved SKN-1/Nrf2 stress response pathway regulates synaptic function in Caenorhabditis elegans

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This small protein molecule plays a vital role in reducing oxidative stress, detoxifying harmful substances, and supporting the immune system

Gardner-Medwin JM, Macdonald IA, Taylor JY, Riley PH, Powell RJ (2001) Seasonal differences in finger skin temperature and microvascular blood flow in healthy men and women are exaggerated in women with primary Raynauds phenomenon