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The TMD of the IR not only anchors the receptor within the plasma membrane but also plays a critical role in transmitting the ligand-binding signal 13
doi: 10.1136/oemed-2019-106012 [DOI] [PMC free article] [PubMed] [Google Scholar] 7.Maserejian N., Vinikoor-Imler L., Dilley A

However, despite a trend towards lower ACTA2 expression in cells treated with the dual agonist, none of these compounds showed capacity to reduce TGF-induced levels of fibrotic markers (Fig

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