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Kong showed that KD can increase antioxidant power and attenuate oxidative stress in spinal cord injury by suppressing class I histone deacetylases

As previously discussed, in this cascade of pathological events ranging from steatosis to inflammation and fibrosis, the dysregulation of the gut-liver axis plays a core role, and taurine has also been found to actively regulate the gut-liver axis

In this context, upregulation of VCAM-1 and integrin 4 expression in tumor-associated LECs, due to the presence of tumor-derived inflammatory factors, leads to weakened LEC junctions, further contributing to increased lymphatic permeability and cancer cell penetration into LVs (157) ( Figure 4A )

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