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Additionally, gene editing and RNA-targeting technologies offer hope for transformative therapies, though challenges remain in ensuring specificity, safety, and long-term efficacy [5558]

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Acknowledgements Figures 1, 2, 3 and 4 in this review were created using BioRender.com ( Funding This work was supported by the National Natural Science Foundation of China [grant numbers 81973498 and 81774283], National Science Foundation For Distinguished Young Scholars [grant numbers 82125037], the Joint Open Project of Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica and Yangtze River Pharmaceutical Group (No

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