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GSH exhibits multiple antioxidant actions, involving direct conjugation with free radicals such as ROS and reactive nitrogen species 46 and enzyme-mediated neutralization of free radicals, including GSH peroxidase (GPx), which detoxifies peroxides with GSH acting as an electron donor 47

Predicting human exposure of active drug after oral prodrug administration, using a joined in vitro/in silico-in vivo extrapolation and physiologically-based pharmacokinetic modeling approach

[DOI] [PubMed] [Google Scholar] 6.Ives HE

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Oxygen activation is often achieved by two mechanisms (Apel and Hirt, 2004): Absorbing excess energy sufficient to rotate the spin of one unpaired electron to make a single state ( 1 O 2 ), during which two electrons are of opposite spin

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