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Defects in the mechanisms that ensure mitochondrial viability, such as mitophagy, are associated with numerous disease states, in particular neurodegenerative diseases such as Parkinson disease (PD)
Brooks, N

In: Verkhratsky, A., Ho, M., Zorec, R., Parpura, V, editors Neuroglia in Neurodegenerative Diseases
doi: 10.1016/j.addr.2012.01.020

The presently available evidence suggests melatonin first appeared in prokaryotes

10.4137/cpath.s487 Clin