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Weight management can be challenging due to factors such as slow metabolism, poor digestion, and reduced energy levels

Moreover, the activation of the signaling pathway is mediated by increased IGF-1 plasma concentration [22]

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All statistical analyses were conducted using the TwoSampleMR (for extracting genetic associations where publicly available and harmonization), MendelianRandomization and MRPRESSO (for deriving MR estimates), and meta package (for assessing heterogeneity in sex differences) in R (version 4.0.1, R Foundation for Statistical Computing, Vienna, Austria)
