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If levels are low, it can impact everything from the mood to the metabolism
DHFR is also required to convert folic acid to DHF

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Mechanisms of apoptosis inhibition by a novel ring-substituted diindolylmethane (1,1-bis[3'-(5-methoxy indolyl)]-1-[p-t-butylphenyl]methane) (BMIPTM) in leukemic cells

P., Gammaitoni, A
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Clinical Investigation 98 (4), 9961003