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Muscle relaxation - Nicotine intervenes with the muscle relaxation of the esophagus, which leads to gastric efflux Esophageal lining - Nicotine damages the mucus membranes which protect the esophageal lining, which triggers the gastric efflux 2

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Interestingly, positive allosteric modulators of nAChRs reverse desensitization caused by nicotine (Pauley, 2008

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