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Baseline and periodic testing of metabolic markers, hormone levels, and organ function provides objective feedback about protocol effects

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Neurological function depends heavily on adequate methylcobalamin for myelin sheath maintenance and neurotransmitter synthesis

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Interestingly, miR-23b targeted HMGA2, which was previously reported to regulate directly IGF2BP2 that enhances IGF2 translation (59, 60)

Transcobalamin receptor (TCblR/CD320) polymorphisms may also impact on serum holoTC concentrations