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That is a genetic-knockdown study in mice, not a drug trial: it tells you the target is real and metabolically meaningful in an animal model, but it does not test a drug, a dose, or a route

Neuroprotective Effects: Offers protection against neurodegenerative diseases by combating oxidative stress in neural tissues

None of the cases exhibited necrosis

(PubMed) Franke B, Vermeulen SH, Steegers-Theunissen RP, et al

They die in an orderly, programmed fashion rather than through necrosis, which would cause inflammation

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